Hospital administrators play an essential role in the implementation of Antibiotic Stewardship Programs, which is instrumental in the fight against antimicrobial resistance. The foundation and sustenance of such programs has been made possible through leadership; this is through interdisciplinary collaboration that is done with policy formulation and stewardship inclusion into the institutional systems. Indeed, it is immense strength where ID physicians and clinical pharmacists with special training proactively involve themselves in the program. Beyond that, the accreditation standards that incorporate ASPs (...) really enhance compliance and institutional commitment. Obstacles to movement include an absence of resources, unwilling prescriber, and other competing health conditions for priority. To achieve such success, the hospital administrators must ensure adequate staffing, proper utilization of advanced technologies, and instillation of accountability through focused education and participation. Besides the reduction of resistance, ASPs contribute to such improvements in patient outcomes, efficient consumption of resources, and significant reductions in costs. As this narrative review indicates, leadership at the hospital level plays an important role in augmenting antibiotic stewardship. Addressing major barriers, along with strategic implementation, means that administrators may play an important role in further maximizing effectiveness while truly adding to the world-wide effort against antimicrobial resistance. (shrink)

Synaesthesia is a condition in which one type of stimulation evokes the sensation of another, as when the hearing of a sound produces photisms, i.e. mental percepts of colours. R is a 20 year old colour blind subject who, in addition to the relatively common grapheme-colour synaesthesia, presents a rarely reported cross modal perception in which a variety of visual stimuli elicit aura-like percepts of colour. In R, photisms seem to be closely related to the affective valence of stimuli and (...) typically bring out a consistent pattern of emotional responses. The present case study suggests that colours might be an intrinsic category of the human brain. We developed an empirical methodology that allowed us to study the subject's otherwise inaccessible phenomenological experience. First, we found that R shows a Stroop effect (delayed response due to interference) elicited by photisms despite the fact that he does not show a regular Stroop with real colours. Secondly, by manipulating the colour context we confirmed that colours can alter R's emotional evaluation of the stimuli. Furthermore, we demonstrated that R's auras may actually lead to a partially inverted emotional spectrum where certain stimuli bring out emotional reactions opposite to the normal ones. These findings can only be accounted for by considering R's subjective colour experience or qualia. Therefore the present paper defends the view that qualia are a useful scientific concept that can be approached and studied by experimental methods. (shrink)

To understand the goals of communist education and shaping of the human being we need deep study of human activity.

Johann Friedrich Ludwig Schröder (1774-1845 ) was born in Germany but moved to Holland at the age of 13. After studying at Halle he joined the Kantian movement in Amsterdam as an active member, cooperating with Paulus van Hemert and contributing articles to his Kantian magazine. During his professional career as a marine instructor (1803-11 ), however, he became increasingly critical of Kantianism. As professor of mathematics, physics and philosophy at the University of Utrecht (1816-44) he traded in his former (...) Kantianism for a variant of the common sense philosophy then in favour in the Netherlands. He now regarded Kantianism as a form of scepticism. Accordingly, in his major work, the Contnbution to a Critique of the Truth of Human Knowledge, he propounds an anti-sceptical doctrine of such ‘basic truths’ as are founded on the immediate relevation of our consciousness. Schröder also attempts to reduce the Kantian doctrine of the noumenon to an inconsistent set of propositions, by showing them to be antinomies in the Kantian sense of the term, even using Kant's own dialectical method in proving their contradictoriness ; these contradictory propositions he calls the 'antinomies of the Kantian philosophy'. In a minor work, The Sign Relation as the Basis of Human Knowledge (translated freely), we find reminiscences of Thomas Reid's Inquiry into the Human Mind: of the doctrine of sensations suggesting our conceptions of things, of causes being the signs of their effects, of 'the natural language of mankind'. Schröder, in developing these ideas in his own way, presents the sign relation as being fundamental to the construction of our knowledge of both nature and the human soul. Only by taking one thing as the ‘sign’ (signal, symbol, symptom, index, expression, picture, representation etc.) of another can we attain a conception of the world as a coherent whole. Our perception of this relation is partly a matter of innate capacities, partly the result of acquired skill. (shrink)

This paper described a formal theory of type judgments for propositional logic notations of PM; I felt the need of my own automated type checker to check their examples. The type checker I wrote did indeed serve to help me referee the paper, but also took a rather different approach to notation and typing for propositional functions of PM, which proved worth writing up independently in our own paper: Holmes, M. Randall, “Polymorphic type– checking for the ramified theory of types (...) of Principia Mathematica”, in Fairouz Kamareddine, ed., Thirty–five Years of Automating Mathematics, Kluwer, 2003, pp. 173-215. (shrink)

Let κ be a regular cardinal, and let B be a subalgebra of an interval algebra of size κ. The existence of a chain or an antichain of size κ in B is due to M. Rubin (see [7]). We show that if the density of B is countable, then the same conclusion holds without this assumption on κ. Next we also show that this is the best possible result by showing that it is consistent with 2 ℵ 0 = (...) ℵ ω 1 that there is a boolean algebra B of size ℵ ω 1 such that length(B) = ℵ ω 1 is not attained and the incomparability of B is less than ℵ ω 1 . Notice that B is a subalgebra of an interval algebra. For more on chains and antichains in boolean algebras see, e.g. [1] and [2]. (shrink)

Для широкого круга читателей (слушателей, аспирантов, преподавателей) интересующихся данной проблемой.